From NYS Thruway: I-90 NYS Thruway west to I-290 North/West. I-290 North/West to I-190 North. Take I-190 across the Grand Island Bridge. Continue on I-190 to exit 24 (Witmer Road). Follow the Niagara University signs along Rt-31 to the campus. Turn right at the light on Hyde Park Blvd.
From North Tonawanda: Niagara Falls Blvd. North to I-190 North (NYS Thruway, Niagara Section). Follow 19 North and exit at Witmer Road. Turn left on Rt-31 to Hyde Park Blvd. Turn right to the University.
From Lockport: Rt. 31 across Military Road to Hyde Park Boulevard. Turn right to the University.
From Canada: Cross the Lewiston-Queenston Bridge and follow Route 104 West to the University.